The study is being funded by the UK National Institute for Health Research Health Technology Assessment programme (NIHR HTA, reference 127337) and the Australian National Health and Medical Research Council (NHMRC; reference 1171206). The views expressed are those of the author(s) and not necessarily those of the UK NIHR, Department of Health and Social Care, or NHMRC.

This study is not funded by any pharmaceutical company. The research is led by a team of experienced doctors and researchers and is sponsored by the University of Bristol (UK) and University of Western Australia. This study was designed and delivered in collaboration with the Bristol Randomised Trials Collaboration (BRTC), a UKCRC registered clinical trial unit (CTU) which, as part of the Bristol Trials Centre (BTC), is in receipt of NIHR CTU support funding.